Interestingly, Thedrez et al. demonstrated that expansion of phosphoantigen-activated Vγ9Vδ2 T cells from peripheral blood mononuclear cells (PBMCs) in the presence of IL-21 and IL-2 promotes their cytolytic function (Th1 function), with increased expression of CD56 and several lytic molecules and also higher tumor-induced degranulation capacity (68). The gene discussed is IL2; the disease is neoplasm.