Recently, Wu et al. demonstrated that, in a colorectal cancer model, activated inflammatory DCs polarize Vγ9Vδ2 cells into γδTh17 cells that secrete high amount of IL-17, but also IL-8, TNF-α, and granulocyte macrophage colony-stimulating factor (GM-CSF) in an IL-23- dependent manner (64). This evidence concerns the gene TNF and colorectal cancer.