Indeed, activated human Vγ9Vδ2 T cells enhance IL-12 production by monocyte-derived DCs through an IFN-γ- and IL-12-mediated positive feedback loop that can then promote naive αβ T cell activation and differentiation into Th1-type cells (127), an effect that may positively influenced the anti-tumor immunity (Figure 1B). This evidence concerns the gene IFNG and neoplasm.