INS and Insulin resistance: Contrary to T3, T1AM does not ameliorate lipid profiles and may cause insulin resistance depending on the dose: intracerebroventricular (icv) injection of T1AM into short-term fasted male mice in a dose of 130 ng/100 gBW (Manni et al., 2012) causes hypophagia as well as peripheral effects namely raised plasma glucose levels and reduced peripheral insulin sensitivity despite increased pancreatic insulin production.