The metaplasia in EL-TGFα/p53+/− mice was characterized along with its genomic signature (Schreiner et al., 2003) and increased expression of Pdx1, a gene necessary for pancreas development and often expressed in pancreatic cancer, was observed in mice with overexpression of TGFα (Song et al., 1999). The gene discussed is TGFA; the disease is pancreatic neoplasm.