The metaplasia in EL-TGFα/p53+/− mice was characterized along with its genomic signature (Schreiner et al., 2003) and increased expression of Pdx1, a gene necessary for pancreas development and often expressed in pancreatic cancer, was observed in mice with overexpression of TGFα (Song et al., 1999). This evidence concerns the gene TGFA and familial pancreatic carcinoma.