IFNA1 and systemic lupus erythematosus: Three anti-IFN-α mAbs, sifalimumab, AGS-009, and rontalizumab, have achieved safety and dose-dependent reduction of IFN-I signature in Phase I SLE trials (Yao et al., 2009; Merrill et al., 2011; Petri et al., 2013; Stohl, 2013).