Several TLR9 polymorphisms have been associated with SLE, particularly in patients of Asian or European ancestry (Tao et al., 2007; Xu et al., 2009; Lu et al., 2011; dos Santos et al., 2012; Huang et al., 2012; Piotrowski et al., 2013; Laska et al., 2014). Here, TLR9 is linked to systemic lupus erythematosus.