Additionally, the modulatory association between the catecholamine degrading enzyme catechol-O-methyltransferase (COMT) and dorso and ventro lateral prefrontal cortex and supragenual anterior cingulate cortex activation during working memory has been demonstrated in schizophrenia (Rasetti and Weinberger, 2011), but remains to be explored in relation to menopausal cognitive decline. Here, COMT is linked to schizophrenia.