We then performed a multivariate analysis (Cox model, n=468) to investigate whether the copy number and/or expression level of each HMT were predictive of poor prognosis compared with standard prognostic markers, including age at diagnosis, ER status, PR status, HER2 status, tumor size, lymph node status, metastasis status, and molecular subtype (basal vs. non-basal). Here, ESR1 is linked to neoplasm.