SMYD3 and breast carcinoma: Among the five most frequently amplified HMT genes (frequency>10%) in breast cancers, four were localized on the long arm of chromosome 1, with SETDB1 at 1q21.3, ASH1L at 1q22, SMYD2 at 1q32.3, and SMYD3 at 1q44 (Figure 4).