Here, we assessed the functional contribution of SKP2 to cancer development in vivo by overexpressing SKP2, either alone or in association with oncogenes that have been associated with hepatocarcinogenesis, such as activated v-Ras neuroblastoma viral oncogene homolog (N-Ras), v-Akt murine thymoma viral oncogene 1 (AKT1), or β-catenin, in the mouse liver via hydrodynamic gene delivery. The gene discussed is SKP2; the disease is cancer.