Subsequent analysis of an additional collection of human HCC (n = 44) whose survival data were missing, showed nuclear accumulation of SKP2 in 11 of 44 (25%) samples, and activation of p-AKT, p-ERK, and β-catenin in 59.1%, 31.9%, and 36,4%, respectively. The gene discussed is AKT1; the disease is hepatocellular carcinoma.