Once again, nuclear accumulation of SKP2 was frequently paralleled by p-AKT and p-ERK activation, as eight of 11 HCC exhibited concomitantly nuclear SKP2 and p-AKT and p-ERK immunoreactivity, whereas only two HCC displayed concomitant nuclear SKP2 and β-catenin accumulation (P < 0.05). Here, SKP2 is linked to hepatocellular carcinoma.