To further investigate the possible relationship between SKP2 and the AKT/mTOR, Ras/MAPK, and Wnt/β-catenin pathways, we analyzed a collection of human HCC specimens (n = 64; Supplementary Table 3) by immunohistochemistry for SKP2, p-AKT, p-ERK, and β-catenin staining (Fig. 6). This evidence concerns the gene MTOR and hepatocellular carcinoma.