FGFR1 and neoplasm: In SCCHN, FGFR1 amplification was significantly associated with poor prognostic factors such as higher T stage, lymphovascular invasion, and higher numbers of visceral metastases.[22]Tumor heterogeneity, unstandardized FISH criteria for FGFR1 amplification, varying adjuvant treatment, and small sample size may contribute to the controversial results.