FGFR1 and neoplasm: Of 45 high FGFR1 amplified tumors, 12 cases (26.7%) only satisfied the criterion of an FGFR1:CEN8 ratio of ≥ 2.0, 7 cases (15.6%) only satisfied the criterion of an average number of FGFR1 signal per nucleus ≥6.0, and 4 cases (8.9%) only satisfied the criterion of percentage of tumor cells containing ≥ 15 FGFR1 signals or large clusters in ≥ 10% cells, respectively.