FGFR1 and head and neck squamous cell carcinoma: FGFR1 amplification occurs significantly more often in the smokers of the lung SqCC, SCCHN, and small cell lung cancer.[16, 22, 23, 26] The proportion of FGFR1 amplification among current smokers were reported 15.8% to 28.9% in lung SqCC and 17.7% in SCCHN in a dose dependent manner.[16, 22, 23] In small cell lung cancer cohort, all FGFR1 amplified cases were current or former smokers.[26] In our study, FGFR1 amplification was significantly more likely to be smokers, and 44 out of 45 high FGFR1 amplification cases were current or former smokers.