FGFR1 amplification occurs significantly more often in the smokers of the lung SqCC, SCCHN, and small cell lung cancer.[16, 22, 23, 26] The proportion of FGFR1 amplification among current smokers were reported 15.8% to 28.9% in lung SqCC and 17.7% in SCCHN in a dose dependent manner.[16, 22, 23] In small cell lung cancer cohort, all FGFR1 amplified cases were current or former smokers.[26] In our study, FGFR1 amplification was significantly more likely to be smokers, and 44 out of 45 high FGFR1 amplification cases were current or former smokers. Here, FGFR1 is linked to small cell lung carcinoma.