FGFR1 and head and neck squamous cell carcinoma: Given the histological similarity and common risk factors, it is not surprising that FGFR1 amplification has been reported in upper aerodigestive tract cancers such as lung SqCC, SCCHN, and small cell lung cancer.[16, 20-28] However, the prognostic significance of FGFR1 amplification in these cancers has shown controversial results.