H2AX and hepatocellular carcinoma: In sum, evaluation of γ-H2AX, EGFR, HIF-1α expression is a powerful predictor of poor prognosis after LT, further supporting a model of γ-H2AX activation of EGFR-HIF-1α-VEGF signaling (Fig. 7) resulting in the angiogenesis of HCC cells.