EGFR and non-small cell lung carcinoma: In the Tarceva In Treatment of Advanced NSCLC (TITAN) study, there was no significant difference in the patients treated with second-line erlotinib and those treated with docetaxel or pemetrexed in the subgroup without EGFR mutation (hazard ratio 0.85, 95% CI 0.59–1.22; p= 0.37) [11].