In addition, CIP2A is overexpressed in NSCLC and correlated with a poor prognosis [12, 15, 18, 21], and the downregulation of CIP2A and inactivation of the AKT pathway has been reported to inhibit proliferation and induce apoptosis in a variety of lung cancer cells [12, 18]. The gene discussed is AKT1; the disease is lung carcinoma.