EGFR and non-small cell lung carcinoma: In the phase 3 Sequential Tarceva in Unresectable NSCLC (SATURN) trial, erlotinib was used as a second-line NSCLC maintenance therapy and showed a better progression-free survival than placebo in the patients without EGFR mutation (hazard ratio 0.78, 95% CI 0.63–0.96; p= 0.0185) [10].