Immunostaining analyses confirmed the presence of Ki67+ proliferative cells in the hair matrix along with the expression of P-cadherin (P-cad), as well as the distribution of the companion layer marker keratin 6 (K6) and the extracellular matrix protein tenascin C (TenC), all in the expected HF locations (Figure 3B). Here, CDH3 is linked to hydrops fetalis.