Moreover, Wnt10a is upregulated during HF development [90], and Wnt10a missense mutations have been associated with the human syndromes odonto-onycho-dermal dysplasia [91] and Schöpf–Schulz–Passarge [92],[93], both characterized for malformations in ectodermal structures. Here, WNT10A is linked to odonto-onycho-dermal dysplasia.