Further studies revealed that ANXA1 can bind to and interact with IKKγ (NEMO) but not IKKα or IKKβ and can recruit RIP1 to the IKK complex, indicating that ANXA1 is crucial for constitutive activation of NF-κB in breast cancer to promote metastasis [7]. Here, NFKB1 is linked to breast carcinoma.