ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Adiponectin is negatively correlated with prolactin [70], as prolactin secretion is reduced in obesity, if adiponectin is produced by the adipose tissue of the mammary gland, negative regulation by prolactin in more adipose women could increase the concentration of adiponectin produced in the mammary tissue, and secreted into breast milk.