Inflammasome activation following HCD was further confirmed using a novel approach to deliver morpholino (MO) oligonucleotides through which knockdown of apoptosis-associated Speck-like protein containing a caspase recruitment domain (ASC) and interleukin 1 β (IL-1β) abrogates HCD-induced intestinal myeloid cell accumulation. This evidence concerns the gene IL1B and heavy chain disease.