To this end, by comparing human liver biopsies with the liver samples of different NAFLD mouse models (HFD-fed C57BL6, MCD-diet fed C57BL6, HC-diet fed APOE*3Leiden, HFD-fed and HFC-diet fed APOE*3Leiden.CETP, HFD-fed and HFC-diet fed LDLR−/−.Leiden and HFD-fed KKAy mice), we first assessed whether specific features of human NAFLD pathology are present in NAFLD mouse models. Here, APOE is linked to metabolic dysfunction-associated steatotic liver disease.