Nevertheless, we do acknowledge the importance of this additional information and although not quantitatively embedded in our scoring system, we did evaluate the zonal patterns of the scored features and types of inflammatory cells in our models and found for C57BL6 on HFD, E3L, E3L.CETP, LDLR−/− and KKAy mice that the pericentral zone was most prominently affected thereby resembling the pathology in humans, whereas for C57BL6 on MCD diet predominantly macrovesicular steatosis around the periportal zone was observed. This evidence concerns the gene LDLR and steatosis.