PEDF expression has been inversely related to metastasis in a variety of cancer types such as gliomas (Guan et al., 2003), lymphangiomas (Sidle et al., 2005), hepatoma (Matsumoto et al., 2004), melanoma (Orgaz et al., 2009), lung cancer (Zhang et al., 2006a), pancreatic cancer (Uehara et al., 2004), and prostate cancer (Halin et al., 2004). This evidence concerns the gene SERPINF1 and Familial prostate cancer.