By carefully analyzing the smoking status, the expression of NER genes and the relapse of bladder cancer, we have derived the conclusion that smoking is not only involved in the relapse of bladder cancer independently, but also combines with NER genes like XPF and XPC to play a malignant role simultaneously, which further aggravated the malignant outcomes of bladder cancer. The gene discussed is NR1H2; the disease is urinary bladder cancer.