Assays for the detection of sE-cad in blood samples of CRC patients were firstly performed by Velikova et al. [47] with the IEMA assay: in CRC patients versus healthy subjects, though elevated in some patients, sE-cad concentrations were not significantly elevated compared with those of the control group, which was different from what was observed for serum concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which were significantly elevated. This evidence concerns the gene CAD and colorectal carcinoma.