In this context, many cancer researches focus on E-cad expression and its modulation: basic structure of E-cadherin protein, posttranslational processing and maturation, genetic variants, gene expression (activation versus silencing), and transcript content/localization have been widely investigated, together with E-cad interactions with multiprotein complexes and signalling variations associated with alterations of E-cad cell-cell adhesion properties [9–12]. The gene discussed is CDH1; the disease is cancer.