Most epithelial tumors loose E-cad partially or completely through mutation, epigenetic silencing, or increased expression of nonepithelial cadherins (colorectal CRC [13]; gastric cancer (GC) [14–16]; breast [17–22]; and GC and breast cancer [23]), and E-cad downregulation globally correlates with tumor grade and invasion. Here, CDH1 is linked to breast cancer.