In addition, germline and somatic inactivating mutations of a putative tumour-suppressor gene, armadillo repeat containing 5 (ARMC5), were recently found in the adrenal glands of about half of patients with bilateral macronodular adrenal hyperplasia (BMAH) (4), and an autosomal dominant mode of inheritance was further characterised (5). Here, ARMC5 is linked to neoplasm.