These clinical observations and previous modeling of medulloblastoma in mice suggested that aberrant activation of the MYC gene family synergizes with inactivation of p53 or Rb in the genesis of biologically aggressive medulloblastoma (Kawauchi et al., 2012; Pei et al., 2012; Shakhova et al., 2006). This evidence concerns the gene RB1 and medulloblastoma.