Relapsed tumors with P53-MYC defects were significantly associated with adverse LCA pathology (Ellison et al., 2011; McManamy et al., 2007) (four of five assessable tumors, 80%, p = 0.0099, Fisher’s exact test), but most did not have distant metastases (five of seven, 71%), suggesting locally aggressive disease (Figure 2E). The gene discussed is MYC; the disease is Leber congenital amaurosis.