MYC and metastatic neoplasm: For high-risk disease, these are MYC gene family (MYC, MYCN) amplification, TP53 mutation, chromosome 17 defects, large-cell anaplastic pathology, metastatic disease, and subtotal surgical resection, whereas favorable-risk disease is defined by the MBWNT subgroup and desmoplastic/nodular pathology in infants (Ellison et al., 2005, 2011; McManamy et al., 2007; Northcott et al., 2012a; Pfister et al., 2009; Pizer and Clifford, 2009; Rutkowski et al., 2009; Ryan et al., 2012; Taylor et al., 2012; Zhukova et al., 2013).