Ornish et al. [83] used a randomized control trial (RCT) design to examine the effect of an entire lifestyle intervention, including low-fat vegan diet supplemented with fish oil and a number of other vitamins and minerals combined with physical activity and stress management techniques, in a group of prostate cancer survivors and examined the effects on the prostate specific antigen (PSA) levels and LNCaP (human prostatic adenocarcinoma) cell growth in vitro. Here, KLK3 is linked to Familial prostate cancer.