The molecular mechanisms by which mTOR activation may favor HCC development include the induction/activation of angiogenesis-related proteins, such as hypoxia-inducible factor 1α and vascular endothelial growth factor, increased cellular proliferation through 4E-BP1, preferential translation of tumor-related genes, upregulation of lipogenesis and of glycolysis and suppression of autophagy [93]. Here, MTOR is linked to hepatocellular carcinoma.