Induction of lipogenesis may be achieved in HCC through activation of the Akt/mTOR axis, which causes an increase in transcription and processing of sterol response element binding protein (SREBP)-1 and the subsequent increase in the expression of several lipogenic genes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and stearoyl-CoA desaturase (SCD) 1 [94]. Here, MTOR is linked to hepatocellular carcinoma.