TNF and rheumatoid arthritis: While reducing TNF secretion could also be a very effective therapeutic strategy not only in rheumatoid arthritis but in many other inflammatory diseases, the labile nature of micelles makes them poor candidates for a therapeutic agent, since they can readily be disassembled in vivo, for example by exchange of lipids with lipoproteins, adsorption onto large proteins, or fusion with cell membranes, followed by dispersion of the component amphiphiles.