FANCG and neoplasm: The differential response of PDAC cells in vitro and in vivo emphasizes the importance of the hypoxic fraction within a tumor for maximal TH-302 efficacy in vivo, as SU.86.86 tumors are highly vascularized and well oxygenated, while Hs766t tumors have large hypoxic fractions [19] and a mutation in the homology-dependent DNA repair (HDR) gene FANCG which makes them more sensitive to the Br-IPM effector [35].