SCGB1A1 and infection: 16 In addition, Scgb1a1−/− mice infected with respiratory syncytial virus display an increased inflammatory response and also, increased viral titer when compared with wild-type animals.21 Mice deficient in SCGB1A1 that are infected with adenovirus also show a more intense inflammatory response.22 Thus, our observations of modulation of SCGB1A1 expression after infection with MHV-68 fit with a role in host defense and/or immunomodulation.