Considering normal sleepers (TST ≥6 h) without OSA as thereference group, the odds ratio (OR) (95% confidence intervals) forhaving HTN was 2.51 (1.35–4.68) in normal sleepers with OSA and 4.37(2.18–8.78) in short sleepers with OSA after adjustment for age, gender,obesity, diabetes, depression, current smoking, use of thyroid hormones, daytimesleepiness, poor sleep complaint, time in bed, sleep architecture andfragmentation, and study site. This evidence concerns the gene TG and obesity due to melanocortin 4 receptor deficiency.