H2AX and ovarian carcinoma: Moreover, it is important to underline that in the literature it is reported that the vit C treatment induces a concentration dependent DSBs in SHIN3 human ovarian cancer cells, due to a time dependence of H2AX phosphorylation [40]–[41] which generates ROS, ATP depletion, and, thus, ATM/AMPK activation and mTOR inhibition, correlated to PI3K signaling pathway [23].