It has been demonstrated that salinomycin induces apoptosis in a spectrum of human cancer cells, including human CD4+ T-cell leukemia cells, Molt-4 cells, Jurkat cells, Namalwa Burkitt lymphoma cells, MES-SA/Dx5 uterine sarcoma cells, cholangiocarcinoma cells (Mz-ChA-1 and TFK-1), which is independent of caspase activation [32], [40]. This evidence concerns the gene CD4 and cholangiocarcinoma.