MYC and Burkitt lymphoma: Common fragile sites with a particular propensity to undergo breakage during replication stress exist in the human genome.23 Two such common fragile sites, FRA8C and FRA8D, flank c-MYC and breakage at these sites have been identified in cervical cancer and Burkitt lymphoma.24 Furthermore, radiation-induced genotoxic stress, which in turn induces replication stress, has been shown to induce breaks at fragile sites in the rat genome.25