The findings of our study and the identification of the PRDM1 risk haplotype strongly suggest an important role for c-MYC overexpression in radiogenic breast cancer development, and we can speculate that radiation-induced c-MYC amplification may be an important driver of c-MYC dysregulation in some, but not all, cases of radiogenic breast cancer. This evidence concerns the gene PRDM1 and breast carcinoma.