EZH2 and breast carcinoma: This is in agreement with a previous study showing that BRCA1 binds directly to EZH2 and inhibits PRC2 activity,20 which regulated histone methylation and the DNA methylation of target genes.16 Consistent with this idea, the expression of BRCA1 could significantly upregulate FOXA1 mRNA expression in basal-like breast cancer cells, including MDA-MB-231 and MDA-MB-436, but not in the luminal cells, such as MCF-7 (Supplementary Figure S6).