Accordingly, the silencing of FOXA1 causes a partial transcriptome shift from luminal to basal gene expression signatures.13 FOXA1 may also prevent metastatic progression of luminal subtype breast cancers by controlling differentiation through enhancing the expression of the negative cell cycle regulator p27Kip1 and the cell adhesion molecule E-cadherin.14 The gene discussed is FOXA1; the disease is breast carcinoma.