FOXA1 and breast cancer: Statistical analysis of the expression and methylation profiles of FOXA1 in these familial breast cancers revealed that there was a strong and significant inverse correlation between FOXA1 methylation and expression using both linear regression model (R2=0.127, P=0.042; Figures 11a and b; Supplementary Figures S7 and S8) and Pearson's correlation model (cutoff is the mean, Pearson correlation coefficient=−0.492, P=0.004; Figure 11c), providing further physiological evidence that FOXA1 methylation negatively regulates its expression in breast cancer patient samples.