A recent study showed that BRCA1 interacts with the PRC2 protein EZH2 to negatively regulate gene expression through promoting histone H3 lysine 27 trimethylation (H3K27me3) in mouse embryonic stem and human breast cancer cells.20 These findings raised the possibility that BRCA1 modulates FOXA1 methylation and expression through recruiting EZH2. This evidence concerns the gene BRCA1 and breast carcinoma.