BRCA1 and breast carcinoma: In fact, promoter methylation has been reported to be a regulatory mechanism for BRCA1 expression and is associated with poor prognosis in breast cancer.25, 26 On the contrary, treatment of the luminal MCF-7 with 5'-aza-dC did not alter the expression levels of FOXA1 (Figure 6c) indicating that, in the presence of wild-type BRCA1, FOXA1 expression is not repressed by DNA methylation.