DC TLR signaling in response to bacterial extracts or CpG-oligodeoxy-nucleotides (ODNs) alone induced IL-12 production and modified the response to peanut antigens by suppressing T-cell proliferation and Th2 cytokine production [128], indicating that activation of TLR9 may be an approach to immunotherapeutic strategies for peanut allergy. This evidence concerns the gene TLR9 and peanut allergic reaction.