To further elucidate the mechanisms through which miR-338-3p reduces HCC resistance to sorafenib, we tested the effect of miR-338-3p on P-gp gene expression, since inducing P-gp protein expression is considered one of the most important mechanisms of HIF-1α on chemoresistance [10], [26]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.