HIF1A and hepatocellular carcinoma: [10]–[12]. As a promising therapeutic target for HCC, HIF-1 when inhibited has been shown to suppress tumor growth and to reverse chemoresistance [13]–[15]. HIF-1 is a heterodimer protein composed of an oxygen-sensitive HIF-1α subunit and a constitutively expressed HIF-1β subunit [16]. Although oxygen-dependent post-translational modification is the primary mechanism of HIF-1α accumulation, HIF-1α can also be transcriptionally and translationally regulated by signaling molecules such as growth factors, cytokines and microRNAs [17].