Echocardiography confirmed cardiac hypertrophy as Trpm4-/- mice exhibited an increase in left ventricular mass (LVM corrected and normalized to BW was 4.10±0.63mg/g, n = 6 vs.3.06±0.1, n = 7 in Trpm4+/+ mice, P<0.01, Table 4 and S1 Supporting Information). Here, TRPM4 is linked to cardiac hypertrophy.