ESR1 and breast carcinoma: The odds ratio for the incidence of breast cancer with well differentiated grade, localized stage, histology ductal, ER status positive and PR status positive for the 3rd quartile (45 lbs, re-scaled to be 0.476) of weight gain versus 1st quartile of weight gain (15 lbs, re-scaled to be 0.190) is 1.356 (exp{(0.476 – 0.190) × 1:066}, 95% confidence interval (CI): 1.164–1.580); (2) the PCL method produced statistically significant estimates ofθ2(2)(1),θ3(2)(1),θ4(2)(1), andθ5(2)(1) for the covariate weight gain, which can be interpreted as follows.