PPARGC1A and type 2 diabetes mellitus: Third, the NGT subjects but not FDRs of T2DM were not included in this study, and the expression of PGC1-α/PPARGC1 was decreased inT2DM and in high-risk non-diabetic subjects with a family history of T2DM[35], giving to the present study an important limitation to assure the conclusions.