Review reports of prenatal ultrasound findings for SHFM noted the detection of bilateral or unilateral split hand foot malformations at gestational age from 11–29 weeks; a TP63 gene mutation, a 22q11.2 deletion for DiGeorge syndrome and a 7q31 deletion was noted in three cases and the genetic etiology for ten cases remained unknown (Table 2) [27-30]. This evidence concerns the gene TP63 and 22q11.2 deletion syndrome.