KIT and cancer: Natural products, such as oridonin, which has been shown to induce the apoptosis of t(8;21) acute myeloid leukemic (AML) cells and inhibit the activity of c-Kit (+) leukemia-initiating cells [21,22], have been considered to play an important role in treating cancer and drug resistance, and they are promising and safe antitumor agents due to their natural origin.