Interestingly, the results of a recent study revealed that the SKP2 SCF complex was a critical E3 ligase for ErbB-receptor-mediated Akt ubiquitination, activation and membrane recruitment, and that SKP2 deficiency inhibited Akt activation and Glut1 expression, leading to repression of breast cancer development [23]. This evidence concerns the gene AKT1 and breast carcinoma.