SKP2 and breast cancer: With regard to the interaction between Akt and SKP2 in breast cancer cell lines, several previous studies have obtained data that were similar to our results, in which the treatment of MCF-7 cells with inhibitor of PI3K (LY294002) was shown to significantly decrease the expression of SKP2 [24], and the use of rapamycin, an mTOR inhibitor, induced cytotoxicity via the suppression of SKP2 in MDA-MB-231 cells [46].