APOE and Cognitive impairment: In the APOE E4 noncarriers, odds ratio (OR) of the UACR values ≥300 mg/g (macroalbuminuria) for cognitive impairment was 1.87 (95% CI, 1.29–2.72) compared to UACR values of <15 mg/g, while in the APOE E4 carriers, OR was 3.56 (1.34–9.42).