These differences can result from specificity and the dose of administered substance, utilized model (including the manner of evoking epilepsy, e.g., by means of pilocarpine, quinolinic acid or picrotoxin), genetic tools, type of examined cells (neurons/microglia/astrocytes) or presence of acidosis (it inhibits P2X7 receptors), which is frequently associated with status epilepticus. The gene discussed is P2RX7; the disease is status epilepticus.