Selected SNPs (single nucleotide polymorphisms) in the P2X7 gene are responsible for increased susceptibility to BDP (bipolar disorder) and MDD (major depressive disorder), and the most commonly studied polymorphisms are Gln460Arg (rs2230912) and His155Tyr (rs208294) [7,41,42,43,103]. This evidence concerns the gene P2RX7 and major depressive disorder.