P2RX7 and depressive disorder: P2X7 receptor and ATP are responsible for increased glutamate release from presynaptic endings, and what is more, they also influence the number of AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors) in presynaptic membrane, that result in excessive synaptic transmission and can contribute to the development of depression disorders [51].