Sifakis et al (16) demonstrated that the levels of cff-DNA increased at an early gestational age (11–13 weeks) in pregnant women who were destined to suffer from severe preeclampsia at a later stage; notably, in women with late (mild) preeclampsia, the cff-DNA levels were similar to those noted in women with normal pregnancies (16). Here, HCFC1 is linked to preeclampsia.