HCFC1 and hyperemesis gravidarum: In addition, cff-DNA appears to play a significant role in women with hyperemesis gravidarum, as a predictor of clinical symptoms, as in a previous study, the concentrations of cff-DNA were found to be significantly higher in 16 women suffering from the disease (range, 21.6–311.2 genome equivalents/ml) compared to 23 women with normal pregnancies (range, 6.6–59.6 genome equivalents/ml) (33).