To determine whether human NSC transplantation could rescue the cognitive impairment associated with hippocampal neuronal loss or age‐dependent Aβ and tau accumulation, immunosuppressed CaM/Tet‐DTA and 3xTg‐AD mice were treated with HuCNS‐SC or vehicle and tested in a series of context‐ and spatial‐dependent behavioral tasks beginning 4 weeks after transplantation. This evidence concerns the gene MAPT and Alzheimer disease.