LYST protein, as an intracellular trafficking regulator whose function is reduced in individuals with CHS, may have a more potent effect on highly regulated cell surface expressed TLRs (e.g. TLR-2 and −4), than intracellular and constitutive TLRs (e.g. TLR-3). The gene discussed is LYST; the disease is Chédiak-Higashi syndrome.