PTEN and cancer: After filtering, the high-confidence deletions overlapped with 26 genes including the following cancer-related genes - PTEN (phosphatase and tensin homolog), which is a key tumour suppressor gene [33], CTNNA3 (catenin alpha 3), which is a cell contact inhibition gene whose mutation can promote cancer development and formation, MCC (mutated in colorectal cancers) and MTUS1 (microtubule associated tumour suppressor 1).