Apart from rev-caspase-3, treatment with non-cytotoxic concentrations of chemotherapeutic agents, including gemcitabine, cisplatin, and topoisomerase I and II inhibitors, are capable of retarding S-phase progression, suggesting that a common mechanism may exist for enhancing cytotoxicities against tumor cells by flavopiridol [20-22]. Here, CASP3 is linked to neoplasm.