The ADH1C gene has been associated with alcohol dependence in many previous studies involving various ethnic groups, including Mexican Americans [15,17], European Americans [47,48], African Americans [47,48], Native Americans [44], Asians [49], Israelis [50], North Africans from Morocco and Southern Europeans from Basque Country [51] and Afro-Caribbeans [52]. Here, ADH1C is linked to alcohol dependence.