Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is a phosphatase that suppresses the activity of the class I phosphoinositide 3-kinase/AKT signalling pathway.1 It has been heavily studied due to its status as a tumour suppressor gene in which loss of function mutations are identified in many sporadic tumours and in the germline of patients with diverse phenotypes. This evidence concerns the gene AKT1 and neoplasm.