In vitro studies by Catalan and co-workers showed a higher MRP8 mRNA expression levels in the stromovascular fraction cells in visceral adipose tissue (VAT) and they suggest a potential role of calprotectin as a chemotactic factor in the recruitment of macrophages to VAT, increasing inflammation and the development of obesity-associated co-morbidities [25]. Here, S100A8 is linked to obesity due to melanocortin 4 receptor deficiency.