After silencing of p53, the cells from the XS11 mammoplastyacquired a deletion on 3p21 starting within PBRM1, the gene encoding the BAF180 subunit of the PBAF ATP-dependentchromatin-remodeling complex [41].Truncating mutations, as seen here, have previously been described in breast cancer,where they reduce p21 induction by TGFβ and p53 [25]. The gene discussed is TP53; the disease is breast cancer.