ADAMTS13 and Genetic thrombotic microangiopathy: The role of plasma exchange has been well established in other conditions such as thrombotic thrombocytopenia purpura, a thrombotic microangiopathy associated with severely depleted levels of A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 Motifs 13 (ADAMTS-13) [5,41].